2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Names and Identifiers

Name	4-hydroxytamoxifen
Synonyms	4-hydroxytamoxifen cis-4-Hydroxytamoxifen trans-4-Hydroxytamoxifen (Z)-3,4-Diphenyl-4-[4-[2-(dimethylamino)ethoxy]phenyl]-3-buten-1-ol 4-(1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol 4-[(E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol 4-{(1Z)-1-[{4-[2-(dimethylamino)ethoxy]phenyl}(phenyl)methylidene]propyl}phenol 2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine N,N-Dimethyl-2-[4-[(E)-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]ethanamine trans-4-Hydroxytamoxifen, (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
CAS	68047-06-3
InChI	InChI=1/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChIKey	TXUZVZSFRXZGTL-OCEACIFDSA-N

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Physico-chemical Properties

Molecular Formula	C26H29NO2
Molar Mass	387.51
Density	1.1005 (rough estimate)
Melting Point	105-107°C
Boling Point	513.45°C (rough estimate)
Flash Point	264.9°C
Solubility	95% ethanol: 20mg/mL
Vapor Presure	3.35E-11mmHg at 25°C
Appearance	powder
Color	white
pKa	10.35±0.15(Predicted)
Storage Condition	2-8°C
Stability	Stable. Store cool. Incompatible with strong oxidizing agents.
Refractive Index	1.6000 (estimate)
MDL	MFCD00278780
In vitro study	4-Hydroxytamoxifen (Monohydroxytamoxifen) is a selective oestrogen receptor antagonist, with an IC 50 of 3.3 nM for the [ 3 H]oestradiol binding to oestrogen receptor. 4-Hydroxytamoxifen (10, 100 nM) enables to inhibit the binding of [ 3 H]oestradiol to the human 8 S oestrogen receptor. 4-Hydroxytamoxifen activates intein-linked inactive Cas9, reduces off-target CRISPR-mediated gene editing. In human cells, conditionally active Cas9s modify target genomic sites with up to 25-fold higher specificity than wild-type Cas9.
In vivo study	4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats. 4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum.

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R63 - Possible risk of harm to the unborn child
Safety Description	S22 - Do not breathe dust. S23 - Do not breathe vapour. S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	SL1210000

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.581 ml	12.903 ml	25.806 ml
5 mM	0.516 ml	2.581 ml	5.161 ml
10 mM	0.258 ml	1.29 ml	2.581 ml
5 mM	0.052 ml	0.258 ml	0.516 ml

Last Update：2024-01-02 23:10:35

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine

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View History

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine
14510-36-2
3-pyrrolidin-1-ium-1-yl-1-(6,7,8,9-tetrahydro-[1]benzofuro[3,2-c]pyridin-8-yl)propan-1-one
Ethanone,2-bromo-1-phenyl-, 2-(2,4-dinitrophenyl)hydrazone
ETHYL 2-PHENYL-4-(1,4-THIAZINAN-4-YL)-5-PYRIMIDINECARBOXYLATE
5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxylic acid
2-Methyl-6-[(3-methoxyphenyl)ethenyl]pyridine
Benzenepropanenitrile, 4-chloro-3-fluoro-β-oxo-
3-Bromo-5-ethyltoluene
524680-42-0

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine

4-hydroxytamoxifen

CAS: 68047-06-3

Molecular Formula: C26H29NO2

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Names and Identifiers

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Physico-chemical Properties

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Risk and Safety

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Preparation solution concentration reference

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2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine Request for Quotation

4-hydroxytamoxifen

CAS: 68047-06-3

Molecular Formula: C26H29NO2

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Names and Identifiers

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Physico-chemical Properties

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Risk and Safety

2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine - Preparation solution concentration reference

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2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine